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No more egg-based flu vaccines, says Fauci; hospitals rationing basic medicines

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pakman 19 oktober 2020 12:09

* Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, believes it is time for the biopharmaceutical industry to move away from the 70-year-old antiquated egg-based process of developing a flu vaccine. This year's flu vaccine was largely ineffective, demonstrating only 36% protection overall.

Fauci noted that some companies are using modern techniques to produce flu vaccines for the U.S. market, like CSL Ltd. unit Seqirus Inc.'s cell-based product Flucelvax and Sanofi subsidiary Protein Sciences Corp.'s recombinant protein-based vaccine Flublok.
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In fact, a recent study has already attributed last year's low flu shot efficacy to the egg-based production process, a theory that the NEJM study supports. As the earlier group of researchers concluded, flu viruses propagated in eggs undergo certain changes in the hemagglutinin protein—the primary target of neutralizing antibodies—and that could negatively impact our body’s virus-killing responses.

With that, scientists now stress the importance of a universal flu vaccine and are championing new paths away from the egg-based manufacturing process.

Recombinant and cell-based platforms are two other vaccine technologies currently available. Sanofi, through its recent acquisition of Protein Sciences, markets the Flublok family, the only recombinant-based flu shots approved in the U.S., and the platform grows vaccine virus in cells. Seqirus’ Flucelvax is also the only FDA-approved cell-based flu vaccine. Seqirus just started manufacturing its entirely cell-based flu vaccines on a commercial scale this season.

In a statement sent to FierceVaccines, Sanofi Pasteur's associate VP and North America regional medical head, David Greenberg, M.D., noted that no clinical studies have conclusively proved that cell-culture vaccines are more effective. He also pointed out that, with 150 million doses of flu shots needed each year in the U.S. alone, “egg-based vaccine production remains the most reliable, time-proven method and represents the vast majority of vaccines used globally to help prevent influenza.”

But the company also said it “continuously assesses new technologies to improve production capabilities,” including the benefits of Flublok and development of a universal flu vaccine that would be effective despite antigenic drift and mismatch.

www.fiercepharma.com/vaccines/egg-bas...

pakman 19 oktober 2020 12:43

yep en het is DE Fauci die nu met Trump steeds in conclaaf ligt, anyway gaat DE Ziekte voor een doorbraak in Pharmings platform zorgen..??
ik denk het wel en zekers bij Positief news al is het nog zo klein.

[verwijderd] 19 oktober 2020 12:46

Dacht het al, kwam me bekend voor.

Ouwe meuk dus.

pakman 19 oktober 2020 12:50

The US keeps millions of chickens in secret farms to make flu vaccines. But their eggs won't work for coronavirus

Across the United States, prized chickens are laying life-saving eggs at secret farms.

Few people know where the chickens are kept -- their locations are undisclosed as a matter of national security.
Each day, hundreds of thousands of their eggs are trucked to facilities, where they are protected by guards and multimillion-dollar, government-funded security systems.
But these eggs aren't for breakfast; they're the source of your common flu shot.
For the past 80 years, much of the world has relied on chicken eggs for the production of influenza vaccines.
About 174.5 million doses of the flu vaccine were distributed across the US this flu season through the end of February, of which an estimated 82% were egg-based, according to the Centers for Disease Control and Prevention (CDC).
With each egg producing one vaccine, that means the US might have used 140 million eggs this flu season alone.
To prepare for annual flu seasons, as well as possible pandemics, the US government has invested tens or hundreds of millions of dollars over the past 15 years to ensure there are enough eggs for vaccines.
But now the world faces a new crisis: the novel coronavirus, which has infected more than 423,000 people globally and killed more than 19,000 since the virus emerged last December, according to Johns Hopkins University.
There is no vaccine yet for the virus; and because it's different than the influenza virus, traditional methods like using eggs won't work. As scientists race to find a cure, the huge US stockpile of eggs won't be of any help.

edition.cnn.com/2020/03/27/health/chi...

er spelen natuurlijk ook nog andere dingen..$$$$$$ hahahaha

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