Wil Helmus schreef op 12 augustus 2020 10:27:
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Hahaha, het gaat allemaal zo snel. Ik kan het niet meer bijhouden. Stukje achtergrondinfo over COPD:
COPD is the third leading cause of death globally, and there is an urgent unmet medical need to develop novel therapeutics specifically for COPD.
Numerous ncRNAs like miRNAs, lncRNAs, and circRNAs, have been linked to COPD. Few of these dysregulated ncRNAs have been functionally characterized. Some ncRNA targets including miR-195, miR-181c, and TUG1 have shown promise in mitigating COPD in vivo.
Significant effort has been made to develop siRNA therapeutics targeting mRNAs critical for the pathogenesis of COPD. siRNAs targeting RIP2, RPS3, MAP3K19, and CHST3 mRNAs have been successfully validated in in vivo COPD models.
Direct inhalation of RNA therapeutics to the lungs is the best route of administration for COPD. Innovative approaches to enhance RNA stability, tissue targeting, cell penetration and intracellular endosomal escape are critical to realize the full potentials of RNA drugs.