Medigene AG (MDG1.DE)
XETRA - XETRA Delayed Price. Currency in EUR 14.88+1.41 (+10.47%)
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Vandaag waren anderen duidelijk aan het (bij)kopen:
Previous Close 13.47
Open 13.88
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Volume 775,671
Avg. Volume 156,125
Ben benieuwd waar dit heen gaat. Hopelijk boven de EUR 18 die eerder is aangetikt.
Het nieuws met blue bio is al weer oud, ook al zal hier verder niemand daar iets van meegekregen hebben: 05/14/2018 Medigene significantly expands TCR alliance with bluebird bio in cancer immunotherapy).
Dit zal wel de aanleiding zijn voor vandaag:
Medigene and Structured Immunity announce collaboration aimed at improving T Cell receptor development
08/21/2018 07:30:00
Planegg - Structured Immunity to evaluate specificity and recognition properties of a lead T cell receptor using proprietary structural immunology platform
Structured Immunity, a biotechnology company specializing in the optimization and validation of T cell receptor (TCR) proteins and Medigene AG, a leading biotechnology company engaged in the development of immunotherapies for the treatment of cancer, today announced a research collaboration where Structured Immunity will provide structural immunology expertise in support of Medigene's TCR discovery activities. Under the terms of the agreement, Medigene will supply Structured Immunity with a lead TCR candidate for a high-profile solid tumor target. Structured Immunity will evaluate the TCR's specificity and recognition properties using their established structural immunology technologies.
The agreement has formally established the relationship between the two companies with a view to further partnerships and collaborative opportunities in the future.
"We are delighted to begin this strategic collaboration with Medigene, a leader in immunotherapy, as together we aim to improve how lead TCR candidates are validated and optimized," said David Hardwicke, co-founder and president at Structured Immunity. "We believe this partnership with Medigene will further showcase and validate our platform technology and demonstrate the value of structural immunology in TCR development." The collaboration will also involve the expertise of the research laboratory of Dr. Brian Baker at the University of Notre Dame, as well as the advice and support of Notre Dame's IDEA Center. "We would like to acknowledge Dr. Baker's scientific input, and thank the IDEA Center for their support in the development of Structured Immunity," said Hardwicke.
Prof. Dolores Schendel, CEO and CSO of Medigene AG, comments: "We are excited to start this new collaboration with Structured Immunity that will focus on the structural interactions between a TCR and the corresponding MHC-peptide complex. As the recognition site between these two complexes is relatively small, it is necessary to determine the exact binding affinities of target peptides. We are convinced that SI's technology can help us to select optimal and highly efficacious TCRs that have the potential to further enhance the efficacy and safety of our approach to bring highly beneficial cellular therapies to the market."
About Medigene's TCR-Ts: The TCR-T technology aims at arming the patient's own T cells with tumor-specific T-cell receptors. The receptor-modified T cells are then able to detect and efficiently kill tumor cells. This immunotherapy approach attempts to overcome the patient's tolerance towards cancer cells and tumor-induced immunosuppression by activating and modifying the patient's T cells outside the body (ex vivo).
TCR-T therapy is developed to utilize a higher number of potential tumor antigens than other T cell-based immunotherapies, such as chimeric antigen receptor T cell (CAR-T) therapy. Medigene's first clinical study with MDG1011 has started 2018 in AML, MM and MDS. The Company is establishing a pipeline of recombinant T-cell receptors and has a collaboration with bluebird bio, Inc. for the development of six TCR-Ts.
About Structured Immunity: Structured Immunity is a US biotechnology company focused on accelerating and de-risking the development of TCR based therapeutics. With extensive expertise in structural and computational biology, Structured Immunity specializes in validating and optimizing TCR specificity. The company is actively forming partnerships with biopharmaceutical companies to enable improved validation and optimization of TCR proteins for safer, more effective therapeutic use.
For more information, please visit structuredimmunity.com